On June 30, 2026, METiS TechBio (7666.HK, "METiS"), a global leader in AI-driven drug delivery innovation company, announced that it has entered into an exclusive global licensing agreement with Boulevard Bio ("Boulevard"), granting Boulevard worldwide development, manufacturing, and commercialization rights for MTS-128, a proprietary trispecific T-cell engager (TCE) program developed by METiS. Under the agreement, METiS will receive a US$20 million upfront payment and is eligible to receive up to US$1.6 billion in development, regulatory, and commercial milestone payments, in addition to tiered royalties on product sales.
METiS TechBio's proprietary NanoForge platform has achieved deep integration across AI-based protein design, drug delivery system engineering, and therapeutic innovation, reflecting validation from top-tier global capital and industry partners. This transaction marks a shift in AI-enabled drug delivery platforms from early technological validation toward global commercialization value realization.
MTS-128 is a next-generation trispecific T-cell engager developed by METiS TechBio through its NanoForge platform. Unlike traditional antibody discovery approaches, MTS-128 is designed and optimized end-to-end through NanoForge-enabled AI-driven molecular engineering, representing a key example of AI-enabled therapeutic innovation at METiS TechBio.
Compared with conventional bispecific T-cell engagers, trispecific TCEs can simultaneously engage multiple biological mechanisms, with the potential to enhance target cell killing efficiency, increase therapeutic window and reduce off-target toxicity. The development of MTS-128 reflects METiS TechBio's integrated capabilities in artificial intelligence and protein engineering, while also demonstrating NanoForge's ability to continuously generate novel therapeutic assets.
In this transaction, Han Kun acted as legal advisor to METiS, and was deeply involved in the whole process of the transaction, including deal structuring, and the drafting, revision and negotiation of the license agreement and other related documents. Leveraging its multidisciplinary expertise, Han Kun delivered comprehensive and in-depth legal services to the client, demonstrating the firm's outstanding capabilities in handling complex cross-border transactions in the life sciences and healthcare sector.
About METiS TechBio
METiS TechBio (7666.HK) is a pioneering TechBio company at the intersection of artificial intelligence and nanomaterial science, focused on transforming the delivery and application of active agents across life forms. On May 13, 2026, METiS successfully listed on HK exchange as the world's first listed company in AI-powered drug delivery.
Founded by a team of MIT-trained scientists with deep expertise in AI, quantum mechanics, nanomaterials, and advanced drug delivery, the company has developed NanoForge, the world's first AI-drive nano-delivery platform and four proprietary platform technologies, AiLNP – AI platform for nucleic acid delivery system design; AiRNA – AI platform for mRNA sequence optimization; AiProtein - AI platform for protein and antibody design and AiTEM – AI platform for small molecule formulation design.
METiS' platforms simulate, predict, and interpret nanoscale interactions to enable rational design, optimization, and validation of next-generation nanomaterials and their payloads. By advancing AI-enabled nanotechnology, METiS strives to unlock new therapeutic possibilities across a wide range of diseases, including cancer, metabolic and autoimmune disorders, and neurodegenerative conditions, and improve the health of lives.
About Han Kun Law Offices
Han Kun is widely recognized and well-known for its practice in life sciences and healthcare. In relevant practice areas, we have been continuously ranked as a first-tier law firm by authoritative legal ranking agencies, including Chambers and Partners, The Legal 500, China Business Law Journal, Asialaw Profiles, etc. Han Kun is committed to providing clients with comprehensive legal services in life sciences and healthcare sector, including private equity and venture capital, mergers and acquisitions, onshore and offshore capital market, pharmaceutical license in/out and asset sale/purchase transactions, intellectual property, data protection, compliance and regulatory, and dispute resolution. Han Kun has a dedicated life sciences and healthcare team led by multiple partners and comprised of tens of specialist attorneys. Our partners on the team all have served a broad range of both domestic and foreign clients and developed a deep understanding of industry regulatory requirements and commercial course of dealings. Our associates on the team are graduates from top law schools both in China and abroad, all fluent in Chinese and English and equipped with excellent legal writing skills. Han Kun is well aware of the importance of professional legal services for life sciences and healthcare companies, especially those facing complex legal issues and therefore requiring special legal support. Clients value our teamwork as we fully leverage the expertise and experience of our professionals, all experts in their respective fields. Our goal is always to provide clients with thorough and practical solutions and high-quality legal services.
